A multifactor complex of eIFI, cIF2, eIF3, eIF5, and tRNAiMet promotes initiation complex assembly and couples GTP hydrolysis to AUG recognition

被引:32
作者
Asano, K [1 ]
Phan, L
Valásek, L
Schoenfeld, LW
Shalev, A
Clayton, J
Nielsen, K
Donahue, TF
Hinnebusch, AG
机构
[1] NICHHD, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA
[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
关键词
D O I
10.1101/sqb.2001.66.403
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:403 / 415
页数:13
相关论文
共 40 条
[31]   eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange [J].
Pavitt, GD ;
Ramaiah, KVA ;
Kimball, SR ;
Hinnebusch, AG .
GENES & DEVELOPMENT, 1998, 12 (04) :514-526
[32]   Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons [J].
Pestova, TV ;
Borukhov, SI ;
Hellen, CUT .
NATURE, 1998, 394 (6696) :854-859
[33]   Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5 [J].
Phan, L ;
Zhang, XL ;
Asano, K ;
Anderson, J ;
Vornlocher, HP ;
Greenberg, JR ;
Qin, J ;
Hinnebusch, AG .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (08) :4935-4946
[34]   A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNAiMet [J].
Phan, L ;
Schoenfeld, LW ;
Valásek, L ;
Nielson, KH ;
Hinnebusch, AG .
EMBO JOURNAL, 2001, 20 (11) :2954-2965
[35]  
PROUD CG, 1992, CURR TOP CELL REGUL, V32, P243
[36]   Starting at the beginning, middle, and end: Translation initiation in eukaryotes [J].
Sachs, AB ;
Sarnow, P ;
Hentze, MW .
CELL, 1997, 89 (06) :831-838
[37]   Related elF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for elF3 integrity and ribosome binding [J].
Valasek, L ;
Phan, L ;
Schoenfeld, LW ;
Valásková, V ;
Hinnebusch, AG .
EMBO JOURNAL, 2001, 20 (04) :891-904
[38]   The Saccharomyces cerevisiae HCR1 gene encoding a homologue of the p35 subunit of human translation initiation factor 3 (eIF3) is a high copy suppressor of a temperature-sensitive mutation in the Rpg1p subunit of yeast eIF3 [J].
Valásek, L ;
Hasek, J ;
Trachsel, H ;
Imre, EM ;
Ruis, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (39) :27567-27572
[39]   A 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes [J].
Vornlocher, HP ;
Hanachi, P ;
Ribeiro, S ;
Hershey, JWB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (24) :16802-16812
[40]   THE SUI1 SUPPRESSOR LOCUS IN SACCHAROMYCES-CEREVISIAE ENCODES A TRANSLATION FACTOR THAT FUNCTIONS DURING TRANS RNAIMET RECOGNITION OF THE START CODON [J].
YOON, HJ ;
DONAHUE, TF .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (01) :248-260