Alphaviruses as vectors for gene delivery

被引：32

作者：

Berglund, P

Tubulekas, I

Liljestrom, P

机构：

[1] Department of Biosciences, Karolinska Institute

来源：

TRENDS IN BIOTECHNOLOGY | 1996年 / 14卷 / 04期

关键词：

D O I：

10.1016/0167-7799(96)10019-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Alphavirus vectors have become an important complement to the systems available for transient expression of cloned sequences in cell culture and in vivo. They express foreign sequences from cytoplasmically self-replicating RNA, which can be delivered into the cell either as RNA or DNA. This article outlines some of the properties of alphavirus expression systems, and discusses the pros and cons underlying their present use in basic research and for in vivo applications.

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收藏

页码：130 / 134

页数：5

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