Tome-1, wee1, and the onset of mitosis: Coupled destruction for timely entry

被引：17

作者：

Lim, HH ^{[1
]}

Surana, U ^{[1
]}

机构：

[1] Inst Mol & Cell Biol, Singapore 117609, Singapore

来源：

MOLECULAR CELL | 2003年 / 11卷 / 04期

关键词：

D O I：

10.1016/S1097-2765(03)00149-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a recent issue of Cell, Ayad et al. (2003) report the identification of a novel F box protein Tome-1, which mediates the destruction of mitosis-inhibitory kinase wee1 via E3 ligase SCR Tome-1 itself is targeted for degradation by APC in G1. This synergy of destructive action by APC and SCF has important implications for timely entry into mitosis.

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页码：845 / 846

页数：2

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