Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry:: towards new potential antimicrobial agents

被引：23

作者：

Castagnolo, Daniele ^{[1
]}

Dessi, Filippo ^{[1
]}

Radi, Marco ^{[1
]}

Botta, Maurizio ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 11期

关键词：

D O I：

10.1016/j.tetasy.2007.06.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral 1-phenyl-2-propynylamines are important building blocks for the synthesis of antifungal and antiaromatase agents related to bifonazole. In this report, a microwave-assisted Cu(l)-catalyzed 'click chemistry' approach has been employed to easily generate a small library of enantiomerically pure alpha-[4-(1-substituted)- 1,2,3-triazol-4-yl]benzylacetamides starting from racemic propargylamines. These compounds could represent easily accessible intermediates for the synthesis of new antimicrobial agents. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1345 / 1350

页数：6

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