RNA: Prebiotic product, or biotic invention?

被引：55

作者：

Anastasi, Carole ^{[1
]}

Buchet, Fabien F. ^{[1
]}

Crowe, Michael A. ^{[1
]}

Parkes, Alastair L. ^{[1
]}

Powner, Matthew W. ^{[1
]}

Smith, James M. ^{[1
]}

Sutherland, John D. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1002/cbdv.200790060

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spectacular advances in structural and molecular biology have added support to the 'RNA world' hypothesis, and provide a mandate for chemistry to explain how RNA might have been generated prebiotically on the early earth. Difficulties in achieving a prebiotically plausible synthesis of RNA, however, have led many to ponder the question posed in the title of this paper. Herein, we review recent experimental work on the assembly of potential RNA precursors, focusing on methods for stereoselective C-C bond construction by aldolisation and related processes. This chemistry is presented in the context of a broader picture of the potential constitutional self-assembly of RNA. Finally, the relative accessibility of RNA and alternative nucleic acids is considered.

引用

页码：721 / 739

页数：19

共 69 条

[1]

ANASTASI C, IN PRESS

[2] Two-step potentially prebiotic synthesis of α-D-cytidine-5′-phosphate from D-glyceraldehyde-3-phosphate [J].

Anastasi, Carole ;

Crowe, Michael A. ;

Sutherland, John D. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (01) :24-25

[3] Direct assembly of nucleoside precursors from two- and three-carbon units [J].

Anastasi, Carole ;

Crowe, Michael A. ;

Powner, Matthew W. ;

Sutherland, John D. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (37) :6176-6179

[4] Pyranosyl-RNA: Further observations on replication [J].

Bolli, M ;

Micura, R ;

Pitsch, S ;

Eschenmoser, A .

HELVETICA CHIMICA ACTA, 1997, 80 (06) :1901-1951

[5] Exploratory studies to investigate a linked prebiotic origin of RNA and coded peptides [J].

Borsenberger, V ;

Crowe, MA ;

Lehbauer, J ;

Raftery, J ;

Helliwell, M ;

Bhutia, K ;

Cox, T ;

Sutherland, JD .

CHEMISTRY & BIODIVERSITY, 2004, 1 (02) :203-246

[6] TNA synthesis by DNA polymerases [J].

Chaput, JC ;

Szostak, JW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (31) :9274-9275

[7] DNA polymerase-mediated DNA synthesis on a TNA template [J].

Chaput, JC ;

Ichida, JK ;

Szostak, JW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (04) :856-857

[8]

COCKERILL AF, 1976, SYNTHESIS-STUTTGART, P591

[9] Studies on the reactivity of bisglycoaldehyde phosphodiester in alkaline solution [J].

Cook, SD ;

Sutherland, JD .

TETRAHEDRON LETTERS, 1996, 37 (32) :5779-5782

[10] Carbonaceous meteorites as a source of sugar-related organic compounds for the early Earth [J].

Cooper, G ;

Kimmich, N ;

Belisle, W ;

Sarinana, J ;

Brabham, K ;

Garrel, L .

NATURE, 2001, 414 (6866) :879-883

← 1 2 3 4 5 6 7 →