Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis

被引:59
作者
Rautureau, Gilles J. P. [1 ]
Day, Catherine L. [2 ]
Hinds, Mark G. [1 ]
机构
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
[2] Univ Otago, Dept Biochem, Dunedin 9054, New Zealand
来源
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2010年 / 11卷 / 04期
关键词
apoptosis; Bcl-2; BH3-only; intrinsically disordered protein; protein structure; CELL-DEATH MACHINERY; DYNEIN LIGHT-CHAIN; BH3-ONLY PROTEINS; FAMILY-MEMBERS; MITOCHONDRIAL-MEMBRANE; UNSTRUCTURED PROTEINS; SIGNALING PATHWAY; CRYSTAL-STRUCTURE; INDUCE APOPTOSIS; STRUCTURAL BASIS;
D O I
10.3390/ijms11041808
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Intrinsic cell death is mediated by interaction between pro-apoptotic and prosurvival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions characterize the interactions within the Bcl-2 family, with conserved sequence motifs on both binding partners required for their molecular recognition.
引用
收藏
页码:1808 / 1824
页数:17
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