共 95 条
Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis
被引:59
作者:

Rautureau, Gilles J. P.
论文数: 0 引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia

Day, Catherine L.
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h-index: 0
机构:
Univ Otago, Dept Biochem, Dunedin 9054, New Zealand Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia

Hinds, Mark G.
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h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
机构:
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
[2] Univ Otago, Dept Biochem, Dunedin 9054, New Zealand
来源:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
2010年
/
11卷
/
04期
关键词:
apoptosis;
Bcl-2;
BH3-only;
intrinsically disordered protein;
protein structure;
CELL-DEATH MACHINERY;
DYNEIN LIGHT-CHAIN;
BH3-ONLY PROTEINS;
FAMILY-MEMBERS;
MITOCHONDRIAL-MEMBRANE;
UNSTRUCTURED PROTEINS;
SIGNALING PATHWAY;
CRYSTAL-STRUCTURE;
INDUCE APOPTOSIS;
STRUCTURAL BASIS;
D O I:
10.3390/ijms11041808
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Intrinsic cell death is mediated by interaction between pro-apoptotic and prosurvival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions characterize the interactions within the Bcl-2 family, with conserved sequence motifs on both binding partners required for their molecular recognition.
引用
收藏
页码:1808 / 1824
页数:17
相关论文
共 95 条
[31]
Promoting apoptosis as a strategy for cancer drug discovery
[J].
Fesik, SW
.
NATURE REVIEWS CANCER,
2005, 5 (11)
:876-885

Fesik, SW
论文数: 0 引用数: 0
h-index: 0
机构:
Abbott Labs, Dept R460, Abbott Pk, IL 60064 USA Abbott Labs, Dept R460, Abbott Pk, IL 60064 USA
[32]
Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes
[J].
Fire, Emiko
;
Gulla, Stefano V.
;
Grant, Robert A.
;
Keating, Amy E.
.
PROTEIN SCIENCE,
2010, 19 (03)
:507-519

Fire, Emiko
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02139 USA MIT, Dept Biol, Cambridge, MA 02139 USA

Gulla, Stefano V.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02139 USA MIT, Dept Biol, Cambridge, MA 02139 USA

Grant, Robert A.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02139 USA MIT, Dept Biol, Cambridge, MA 02139 USA

Keating, Amy E.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02139 USA MIT, Dept Biol, Cambridge, MA 02139 USA
[33]
Baxβ: A Constitutively Active Human Bax Isoform that Is under Tight Regulatory Control by the Proteasomal Degradation Mechanism
[J].
Fu, Nai Yang
;
Sukumaran, Sunil K.
;
Kerk, Sze Yen
;
Yu, Victor C.
.
MOLECULAR CELL,
2009, 33 (01)
:15-29

Fu, Nai Yang
论文数: 0 引用数: 0
h-index: 0
机构:
Agcy Sci Technol & Res, Inst Mol & Cell Biol, Singapore 138673, Singapore Agcy Sci Technol & Res, Inst Mol & Cell Biol, Singapore 138673, Singapore

Sukumaran, Sunil K.
论文数: 0 引用数: 0
h-index: 0
机构:
Agcy Sci Technol & Res, Inst Mol & Cell Biol, Singapore 138673, Singapore Agcy Sci Technol & Res, Inst Mol & Cell Biol, Singapore 138673, Singapore

Kerk, Sze Yen
论文数: 0 引用数: 0
h-index: 0
机构:
Agcy Sci Technol & Res, Inst Mol & Cell Biol, Singapore 138673, Singapore Agcy Sci Technol & Res, Inst Mol & Cell Biol, Singapore 138673, Singapore

Yu, Victor C.
论文数: 0 引用数: 0
h-index: 0
机构:
Agcy Sci Technol & Res, Inst Mol & Cell Biol, Singapore 138673, Singapore
Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacognosy, Singapore 117597, Singapore Agcy Sci Technol & Res, Inst Mol & Cell Biol, Singapore 138673, Singapore
[34]
Membrane promotes tBID interaction with BCLXL
[J].
Garcia-Saez, Ana J.
;
Ries, Jonas
;
Orzaez, Mar
;
Perez-Paya, Enrique
;
Schwille, Petra
.
NATURE STRUCTURAL & MOLECULAR BIOLOGY,
2009, 16 (11)
:1178-U9

Garcia-Saez, Ana J.
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Dresden, BIOTEC, Biophys Grp, Dresden, Germany Tech Univ Dresden, BIOTEC, Biophys Grp, Dresden, Germany

论文数: 引用数:
h-index:
机构:

Orzaez, Mar
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Invest Principe Felipe, Dept Med Chem, Valencia, Spain Tech Univ Dresden, BIOTEC, Biophys Grp, Dresden, Germany

Perez-Paya, Enrique
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Invest Principe Felipe, Dept Med Chem, Valencia, Spain
Inst Biomed Valencia, Consejo Super Invest Cient, Valencia, Spain Tech Univ Dresden, BIOTEC, Biophys Grp, Dresden, Germany

Schwille, Petra
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Dresden, BIOTEC, Biophys Grp, Dresden, Germany Tech Univ Dresden, BIOTEC, Biophys Grp, Dresden, Germany
[35]
BAX activation is initiated at a novel interaction site
[J].
Gavathiotis, Evripidis
;
Suzuki, Motoshi
;
Davis, Marguerite L.
;
Pitter, Kenneth
;
Bird, Gregory H.
;
Katz, Samuel G.
;
Tu, Ho-Chou
;
Kim, Hyungjin
;
Cheng, Emily H. -Y.
;
Tjandra, Nico
;
Walensky, Loren D.
.
NATURE,
2008, 455 (7216)
:1076-U6

Gavathiotis, Evripidis
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
Dana Farber Canc Inst, Program Canc Chem Biol, Boston, MA 02115 USA
Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Suzuki, Motoshi
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA
Dana Farber Canc Inst, Program Canc Chem Biol, Boston, MA 02115 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Davis, Marguerite L.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
Dana Farber Canc Inst, Program Canc Chem Biol, Boston, MA 02115 USA
Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Pitter, Kenneth
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
Dana Farber Canc Inst, Program Canc Chem Biol, Boston, MA 02115 USA
Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Bird, Gregory H.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
Dana Farber Canc Inst, Program Canc Chem Biol, Boston, MA 02115 USA
Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Katz, Samuel G.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Tu, Ho-Chou
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Kim, Hyungjin
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Cheng, Emily H. -Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Tjandra, Nico
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA

Walensky, Loren D.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
Dana Farber Canc Inst, Program Canc Chem Biol, Boston, MA 02115 USA
Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA
[36]
The N terminus of the anti-apoptotic BCL-2 homologue MCL-1 regulates its localization and function
[J].
Germain, Marc
;
Duronio, Vincent
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2007, 282 (44)
:32233-32242

Germain, Marc
论文数: 0 引用数: 0
h-index: 0
机构: Univ British Columbia, Dept Med, Vancouver, BC V6H 3Z6, Canada

Duronio, Vincent
论文数: 0 引用数: 0
h-index: 0
机构: Univ British Columbia, Dept Med, Vancouver, BC V6H 3Z6, Canada
[37]
Characterization of the BH3 protein Bmf in Gallus gallus:: Identification of a novel chicken-specific isofonn
[J].
Gomez-Esquer, Francisco
;
Palomar, Ma. Angustias
;
Rivas, Ines
;
Delcan, Jose
;
Linares, Rafael
;
Diaz-Gil, Gema
.
GENE,
2008, 407 (1-2)
:21-29

Gomez-Esquer, Francisco
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain

Palomar, Ma. Angustias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain

Rivas, Ines
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain

Delcan, Jose
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain

Linares, Rafael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain

Diaz-Gil, Gema
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Salud 3, E-28922 Madrid, Spain
[38]
Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2
[J].
Grandgirard, D
;
Studer, E
;
Monney, L
;
Belser, T
;
Fellay, I
;
Borner, C
;
Michel, MR
.
EMBO JOURNAL,
1998, 17 (05)
:1268-1278

Grandgirard, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland

Studer, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland

Monney, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland

Belser, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland

Fellay, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland

Borner, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland

Michel, MR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland
[39]
Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation
[J].
Gsponer, Jorg
;
Futschik, Matthias E.
;
Teichmann, Sarah A.
;
Babu, M. Madan
.
SCIENCE,
2008, 322 (5906)
:1365-1368

Gsponer, Jorg
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Mol Biol Lab, Cambridge CB2 0QH, England MRC, Mol Biol Lab, Cambridge CB2 0QH, England

Futschik, Matthias E.
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Mol Biol Lab, Cambridge CB2 0QH, England
Humboldt Univ, Inst Theoret Biol, D-10115 Berlin, Germany
Univ Algarve, Inst Biotechnol & Bioengn, Ctr Mol & Struct Biomed, P-8005139 Faro, Portugal MRC, Mol Biol Lab, Cambridge CB2 0QH, England

Teichmann, Sarah A.
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Mol Biol Lab, Cambridge CB2 0QH, England MRC, Mol Biol Lab, Cambridge CB2 0QH, England

Babu, M. Madan
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Mol Biol Lab, Cambridge CB2 0QH, England MRC, Mol Biol Lab, Cambridge CB2 0QH, England
[40]
INACTIVATION OF BCL-2 BY PHOSPHORYLATION
[J].
HALDAR, S
;
JENA, N
;
CROCE, CM
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1995, 92 (10)
:4507-4511

HALDAR, S
论文数: 0 引用数: 0
h-index: 0
机构:
THOMAS JEFFERSON UNIV,JEFFERSON CANC CTR,PHILADELPHIA,PA 19107 THOMAS JEFFERSON UNIV,JEFFERSON CANC CTR,PHILADELPHIA,PA 19107

JENA, N
论文数: 0 引用数: 0
h-index: 0
机构:
THOMAS JEFFERSON UNIV,JEFFERSON CANC CTR,PHILADELPHIA,PA 19107 THOMAS JEFFERSON UNIV,JEFFERSON CANC CTR,PHILADELPHIA,PA 19107

CROCE, CM
论文数: 0 引用数: 0
h-index: 0
机构:
THOMAS JEFFERSON UNIV,JEFFERSON CANC CTR,PHILADELPHIA,PA 19107 THOMAS JEFFERSON UNIV,JEFFERSON CANC CTR,PHILADELPHIA,PA 19107