Diastereoselective hydrogenation of 4-(phosphonomethyl)-2-pyridinecarboxylic acid

被引：12

作者：

Steiner, H ^{[1
]}

Giannousis, P

Pische-Jacques, A

Blaser, HU

机构：

[1] Novartis Serv AG, Catalysis Serv, CH-4002 Basel, Switzerland

[2] Novartis Serv AG, Synth Serv, CH-4002 Basel, Switzerland

[3] Novartis Pharma AG, Chem & Analyt Dev, CH-4002 Basel, Switzerland

来源：

TOPICS IN CATALYSIS | 2000年 / 13卷 / 03期

关键词：

diastereoselective hydrogenation; palladium-rhodium; mixed metal catalyst; substituted pyridines;

D O I：

10.1023/A:1009069913798

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A Pd-Rh mixed metal catalytic system was developed that is able to hydrogenate 4-(phosphonomethyl)-2-pyridinecarboxylic acid to give 4-(phosphonomethyl)-2-piperidinecarboxylic acid with a cis selectivity of up to 98% with acceptable reaction time and without leading to metal contamination of the product.

引用

页码：191 / 194

页数：4

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