Preparation of highly functionalized heterocyclic zinc organometallics via a Li(acac)-catalysis of the I/Zn-exchange reaction

被引：35

作者：

Gong, LZ ^{[1
]}

Knochel, P ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

SYNLETT | 2005年 / 02期

关键词：

polyfunctional heterocycles; iodine-zinc exchange reaction; diorganozinc reagent; catalysis; cross-coupling;

D O I：

10.1055/s-2004-837206

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of i-Pr2Zn in the presence of catalytic amount of Li(acac) in NMP with various functionalized heterocyclic iodides provides new polyfunctional diheteroarylzincs, which undergo smooth Negishi cross-coupling reactions and CuCN.2LiCl-catalyzed allylation reactions under mild conditions. Remarkably, even an aldehyde function can be present in the diorganozinc reagents.

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页码：267 / 270

页数：4

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