The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

被引：856

作者：

Choi, Gloria B. ^{[1
]}

Yim, Yeong S. ^{[1
]}

Wong, Helen ^{[2
,3
]}

Kim, Sangdoo ^{[4
,5
]}

Kim, Hyunju ^{[4
,5
]}

Kim, Sangwon V. ^{[6
]}

Hoeffer, Charles A. ^{[2
,3
]}

Littman, Dan R. ^{[6
,7
]}

Huh, Jun R. ^{[4
,5
,6
]}

机构：

[1] MIT, Dept Brain & Cognit Sci, McGovern Inst Brain Res, E25-618, Cambridge, MA 02139 USA

[2] NYU, Ctr Neural Sci, New York, NY 10003 USA

[3] Univ Colorado, Dept Integrated Physiol, Inst Behav Genet, Boulder, CO 80303 USA

[4] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Dept Med, Worcester, MA 01605 USA

[5] Univ Massachusetts, Sch Med, Dept Med, Program Innate Immun, Worcester, MA 01605 USA

[6] NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA

[7] Howard Hughes Med Inst, New York, NY 10016 USA

来源：

SCIENCE | 2016年 / 351卷 / 6276期

基金：

新加坡国家研究基金会;

关键词：

IMMUNE ACTIVATION; ROR-GAMMA; PROINFLAMMATORY IL-17(+); TH17; CELLS; FAMILY; DIFFERENTIATION; HOSPITALIZATION; ABNORMALITIES; INFECTION; PREGNANCY;

D O I：

10.1126/science.aad0314

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The SPO11 protein catalyzes the formation of meiotic DNA double strand breaks (DSBs) and is homologous to theAsubunit of an archaeal topoisomerase (topo VI). Topo VI are heterotetrameric enzymes comprising two A and two B subunits; however, no topo VIBinvolved inmeiotic recombination had been identified. We characterized a structural homolog of the archaeal topo VIB subunit [meiotic topoisomerase VIB-like (MTOPVIB)], which is essential for meiotic DSB formation. It forms a complexwith the two Arabidopsis thaliana SPO11 orthologs required for meiotic DSB formation (SPO11-1 and SPO11-2) and is absolutely required for the formation of the SPO11-1/SPO11-2 heterodimer. These findings suggest that the catalytic core complex responsible for meiotic DSB formation in eukaryotes adopts a topo VI-like structure.

引用

页码：933 / 939

页数：7

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