(3-pyridazinamin-3-yl)α-amino acids:: A facilitated method of preparation of phenylalanine and proline representatives

被引：7

作者：

Chayer, S

Essassi, EM

Bourguignon, JJ

机构：

[1] Fac Pharm, Lab Pharmacochim Mol, F-67401 Illkirch, France

[2] Univ Mohamed V, Fac Sci, Lab Chim Organ Heterocycl, Rabat, Morocco

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(97)10745-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The presence of an easy removable cyano group in position 4 of 3-chloropyridazines increased significantly their reactivity towards nucleophiles including alpha-aminoacids. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：841 / 844

页数：4

共 9 条

[1] REGIOSELECTIVE ALKYLATION OF THE EXOCYCLIC NITROGEN OF HETEROCYCLIC AMIDINES VIA THE MITSUNOBU REACTION [J].

ABARGHAZ, M ;

KERBAL, A ;

BOURGUIGNON, JJ .

TETRAHEDRON LETTERS, 1995, 36 (36) :6463-6466

[2] ONE-POT SYNTHESIS OF N-(2-HETEROARYL)-ALPHA-AMINO ESTERS BY THE REGIOSPECIFIC 2-N-(ALPHA-ALKOXYCARBONYL)ALKYLATION OF 2-AMINOAZINES AND 2-AMINOAZOLES WITH GLYOXALS AND ALCOHOLS PROMOTED BY PERCHLORIC-ACID [J].

ALCAIDE, B ;

PLUMET, J ;

SIERRA, MA .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (10) :3143-3147

[3] SYNTHESIS AND FUNCTIONAL-EVALUATION OF A PEPTIDE DERIVATIVE OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE [J].

BALAJTHY, Z ;

ARADI, J ;

KISS, IT ;

ELODI, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (18) :3344-3349

[4]

GANTE J, 1994, ANGEW CHEM INT EDIT, V33, P1699, DOI 10.1002/anie.199416991

[5] PYRIDAZINES .35. PREPARATION OF SOME NOVEL PYRIMIDO[4,5-C]PYRIDAZINE DERIVATIVES FROM 3-ALKYLAMINO-4-PYRIDAZINECARBOXAMIDES AND 3-ARYLAMINO-4-PYRIDAZINECARBOXAMIDES [J].

HAIDER, N ;

HEINISCH, G ;

LASSNIGG, D .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1988, 25 (01) :119-124

[6]

MAGHIOROS G, 1983, NOUV J CHIM, V7, P667

[7]

TOUSSAINT D, 1994, HETEROCYCLES, V38, P1273

[8] AMINATION .3. TRIMETHYLSILANOL AS LEAVING GROUP .5. SILYLATION AMINATION OF HYDROXY N-HETEROCYCLES [J].

VORBRUGGEN, H ;

KROLIKIEWICZ, K .

CHEMISCHE BERICHTE-RECUEIL, 1984, 117 (04) :1523-1541

[9] 3-AMINOPYRIDAZINE DERIVATIVES WITH ATYPICAL ANTIDEPRESSANT, SEROTONERGIC, AND DOPAMINERGIC ACTIVITIES [J].

WERMUTH, CG ;

SCHLEWER, G ;

BOURGUIGNON, JJ ;

MAGHIOROS, G ;

BOUCHET, MJ ;

MOIRE, C ;

KAN, JP ;

WORMS, P ;

BIZIERE, K .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (03) :528-537

← 1 →