Design and synthesis of α,β-unsaturated carbonyl compounds as potential ACE inhibitors

被引：23

作者：

Choo, HYP ^{[1
]}

Peak, KH

Park, J

Kim, DH

Chung, HS

机构：

[1] Ewha Womans Univ, Sch Pharm, Seoul 120750, South Korea

[2] Korea Inst Sci & Technol, Doping Control Ctr, Seoul 130650, South Korea

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 35卷 / 06期

关键词：

alpha; beta-unsaturated amides; angiotensin converting enzyme inhibitor irreversible inhibitors;

D O I：

10.1016/S0223-5234(00)00158-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The alpha,beta-unsaturated amide that is incorporated into the basic structural frame of a simple substrate molecule of angiotensin converting enzyme was found to serve as a Michael acceptor for the catalytic carboxylate of Glu-127, inhibiting the enzyme irreversibly. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：643 / 648

页数：6

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