Atg5 and Bcl-2 provide novel insights into the interplay between apoptosis and autophagy

被引:128
作者
Luo, S. [1 ]
Rubinsztein, D. C. [1 ]
机构
[1] Addenbrookes Hosp, Dept Med Genet, Med Res Inst, Cambridge CB2 2XY, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1038/sj.cdd.4402149
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1247 / 1250
页数:5
相关论文
共 31 条
[1]   Rapamycin alleviates toxicity of different aggregate-prone proteins [J].
Berger, Z ;
Ravikumar, B ;
Menzies, FM ;
Oroz, LG ;
Underwood, BR ;
Pangalos, MN ;
Schmitt, I ;
Wullner, U ;
Evert, BO ;
O'Kane, CJ ;
Rubinsztein, DC .
HUMAN MOLECULAR GENETICS, 2006, 15 (03) :433-442
[2]   Inhibition of macroautophagy triggers apoptosis [J].
Boya, P ;
González-Polo, RA ;
Casares, N ;
Perfettini, JL ;
Dessen, P ;
Larochette, N ;
Métivier, D ;
Meley, D ;
Souquere, S ;
Yoshimori, T ;
Pierron, G ;
Codogno, P ;
Kroemer, G .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (03) :1025-1040
[3]   Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells [J].
Canu, N ;
Tufi, R ;
Serafino, AL ;
Amadoro, G ;
Ciotti, MT ;
Calissano, P .
JOURNAL OF NEUROCHEMISTRY, 2005, 92 (05) :1228-1242
[4]  
Cárdenas-Aguayo MD, 2003, J HEMATOTH STEM CELL, V12, P735
[5]   Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins [J].
Gillooly, DJ ;
Simonsen, A ;
Stenmark, H .
BIOCHEMICAL JOURNAL, 2001, 355 :249-258
[6]   Autophagy as a cell death and tumor suppressor mechanism [J].
Gozuacik, D ;
Kimchi, A .
ONCOGENE, 2004, 23 (16) :2891-2906
[7]   Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice [J].
Hara, Taichi ;
Nakamura, Kenji ;
Matsui, Makoto ;
Yamamoto, Akitsugu ;
Nakahara, Yohko ;
Suzuki-Migishima, Rika ;
Yokoyama, Minesuke ;
Mishima, Kenji ;
Saito, Ichiro ;
Okano, Hideyuki ;
Mizushima, Noboru .
NATURE, 2006, 441 (7095) :885-889
[8]   Autophagy in yeast: A review of the molecular machinery [J].
Huang, WP ;
Klionsky, DJ .
CELL STRUCTURE AND FUNCTION, 2002, 27 (06) :409-420
[9]   A ubiquitin-like system mediates protein lipidation [J].
Ichimura, Y ;
Kirisako, T ;
Takao, T ;
Satomi, Y ;
Shimonishi, Y ;
Ishihara, N ;
Mizushima, N ;
Tanida, I ;
Kominami, E ;
Ohsumi, M ;
Noda, T ;
Ohsumi, Y .
NATURE, 2000, 408 (6811) :488-492
[10]   Structural and functional analyses of APG5, a gene involved in autophagy in yeast [J].
Kametaka, S ;
Matsuura, A ;
Wada, Y ;
Ohsumi, Y .
GENE, 1996, 178 (1-2) :139-143