Copper-tyrosyl radical enzymes

被引：68

作者：

Rogers, MS ^{[1
]}

Dooley, DM ^{[1
]}

机构：

[1] Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59717 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(03)00024-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances have been made since 2000 that contribute to our understanding of the biogenesis, structure and mechanism of copper-containing tyrosyl radical enzymes. Efforts to detail the biogenesis of galactose oxidase have produced the structure of the precursor enzyme, which provides a framework for emerging mechanistic studies. The role of the tyrosyl radical of cytochrome c oxidase is being defined in studies that aim to understand the His-Tyr crosslink, the location of the radical and, by direct attempts, to provide evidence for the radical during turnover.

引用

页码：189 / 196

页数：8

共 56 条

[21]

Knappe J, 2001, ADV PROTEIN CHEM, V58, P277

[22]

KNOWLES PF, 1993, PERSP BIOIN, V2, P207

[23] Mono- and dinuclear (o-thioetherphenolato)-copper(II) complexes.: Structural models for galactose oxidase [J].

Kruse, T ;

Weyhermüller, T ;

Wieghardt, K .

INORGANICA CHIMICA ACTA, 2002, 331 :81-89

[24] Syntheses of new hydroxy-[3.3]orthocyclophanes as models for the galactose oxidase Tyr-Cys cofactor [J].

Liu, XM ;

Barrett, SA ;

Kilner, CA ;

Thornton-Pett, M ;

Halcrow, MA .

TETRAHEDRON, 2002, 58 (03) :603-611

[25] Direct evidence for a tyrosine radical in the reaction of cytochrome c oxidase with hydrogen peroxide [J].

MacMillan, F ;

Kannt, A ;

Behr, J ;

Prisner, T ;

Michel, H .

BIOCHEMISTRY, 1999, 38 (29) :9179-9184

[26] Insights into the functional role of the tyrosine-histidine linkage in cytochrome c oxidase [J].

McCauley, KM ;

Vrtis, JM ;

Dupont, J ;

van der Donk, WA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (10) :2403-2404

[27]

MCPHERSON MJ, 2001, HDB METALLOPROTEINS, P1272

[28] The mechanism of proton pumping by cytochrome c oxidase [J].

Michel, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :12819-12824

[29] Role of the PR intermediate in the reaction of cytochrome c oxidase with O2 [J].

Morgan, JE ;

Verkhovsky, MI ;

Palmer, G ;

Wikström, M .

BIOCHEMISTRY, 2001, 40 (23) :6882-6892

[30] Structure at 2.7 angstrom resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody F-V fragment [J].

Ostermeier, C ;

Harrenga, A ;

Ermler, U ;

Michel, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10547-10553

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