Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease

被引：21

作者：

Gan, Li ^{[1
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA

来源：

DRUG NEWS & PERSPECTIVES | 2007年 / 20卷 / 04期

关键词：

NF-KAPPA-B; SIR2 HISTONE/PROTEIN DEACETYLASES; PROTEIN DEACETYLASES; CELL-SURVIVAL; LIFE-SPAN; TRANSCRIPTION FACTORS; CALORIE RESTRICTION; SACCHAROMYCES-CEREVISIAE; MITOCHONDRIAL-FUNCTION; AMYLOID HYPOTHESIS;

D O I：

10.1358/dnp.2007.20.4.1101162

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sirtuins, known as silent information regulators, are class III histone deacetylases (HDAC) that catalyze deacetylation reaction in an NAD(+)-dependent manner. Evolutionarily conserved from bacteria to humans, sirtuins regulate important cell functions by deacetylating histone and nonhistone targets. Activation of sirtuin extends lifespan and promotes longevity and healthy aging in a variety of species, potentially delaying the onset of age-related neurodegenerative disorders. In mammalian systems, sirtuin activators protect against axonal degeneration, poly-glutamine toxicity and microglia-mediated amyloid 0 toxicity, suggesting the potential therapeutic value of sirtuins in patients with neurodegenerative diseases, such as Alzheimer's disease. In this review, we discuss the potential role of the sirtuin pathway in modifying the pathogenic processes in Alzheimer's disease. (C) 2007 Prous Science. All rights reserved.

引用

页码：233 / 239

页数：7

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