Selective one-pot synthesis of symmetrically and unsymmetrically substituted amines via rhodium catalysed multiple alkylations of ammonia or primary amines under hydroformylation conditions

被引：60

作者：

Rische, T ^{[1
]}

Kitsos-Rzychon, B ^{[1
]}

Eilbracht, P ^{[1
]}

机构：

[1] Univ Dortmund, FB 3, D-44221 Dortmund, Germany

来源：

TETRAHEDRON | 1998年 / 54卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(98)83008-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Symmetrically and unsymmetrically substituted secondary and tertiary amines are selectively prepared in high yields by a one-pot multiple alkylation procedure from ammonia or primary amines with styrenes and/or cyclic olefins, carbon monoxide and hydrogen in the presence of [Rh(cod)Cl](2) as catalyst. Similarly unsymmetrically substituted tertiary amines are obtained under hydroformylation conditions from primary amines by a one-pot reductive bisalkylation procedure using preformed aldehydes or ketones in one step and the hydroformylation products in the second step of a combined amine condensation-reduction-hydroaminomethylation reaction sequence. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2723 / 2742

页数：20

共 40 条

[1] Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures [J].