Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

被引：526

作者：

McNew, JA ^{[1
]}

Parlati, F ^{[1
]}

Fukuda, R ^{[1
]}

Johnston, RJ ^{[1
]}

Paz, K ^{[1
]}

Paumet, F ^{[1
]}

Söllner, TH ^{[1
]}

Rothman, JE ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USA

来源：

NATURE | 2000年 / 407卷 / 6801期

关键词：

D O I：

10.1038/35025000

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Membrane-enveloped vesicles travel among the compartments of the cytoplasm of eukaryotic cells, delivering their specific cargo to programmed locations by membrane fusion. The pairing of vesicle v-SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) with target membrane t-SNAREs has a central role in intracellular membrane fusion. We have tested all of the potential v-SNAREs encoded in the yeast genome for their capacity to trigger fusion by partnering with t-SNAREs that mark the Golgi, the vacuole and the plasma membrane. Here we rnd that, to a marked degree, the pattern of membrane flow in the cell is encoded and recapitulated by its isolated SNARE proteins, as predicted by the SNARE hypothesis.

引用

页码：153 / 159

页数：7

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