Easy copper-, ligand- and amine-free sonogashira coupling reaction catalyzed by palladium on carbon at low catalyst loading and by exposure to air

被引:36
作者
Zhang, GL [1 ]
机构
[1] Zhejiang Univ, Coll Pharmaceut Sci, Dept Med Chem, Hangzhou 310031, Peoples R China
关键词
sonogashira coupling; palladium; catalysis; heterogeneous;
D O I
10.1055/s-2005-863720
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An easy copper-, ligand and amine-free Sonogashira coupling reaction catalyzed by commercially available palladium on carbon with air at low catalyst loading (0.2 mol% Pd) has been developed. Aryl iodides coupled with aromatic alkynes gave good to excellent yields and with aliphatic alkyne gave moderate to good yields. The reaction system is easy to handle.
引用
收藏
页码:619 / 622
页数:4
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