New polyoxometalate/starch nanomaterial: synthesis, characterization and antitumoral activity

被引：134

作者：

Wang, XH

Liu, JF ^{[1
]}

Pope, MT

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

[2] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

来源：

DALTON TRANSACTIONS | 2003年 / 05期

关键词：

D O I：

10.1039/b300920n

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Using a reversed-phase microemulsion polymerization method, polyoxometalate (POM) CoW11TiO40 loaded starch nanoparticles have been prepared and structurally characterized by elemental analyses, IR spectra, UV-vis and ESR spectroscopy. The particle size of CoW11TiO40/starch was estimated by transmission electron microscopy (TEM) and the size ranges by a 1000HSA MALVIRN Zetasizer instrument. The results show that the POMs retained the parent structure after encapsulated by starch microspheres, which are able to enhance the stability and antitumoral activity of POMs and also decrease the toxicity of the POM.

引用

页码：957 / 960

页数：4

共 16 条

[1]

Bergsson J, 1997, STARCH 96 BOOK, P105

[2]

BLASECKI JW, 1994, THERAPY TOXICITY TUN

[3]

CARR ME, 1991, CEREAL CHEM, V68, P262

[4] THE COMBINATION OF DEGRADABLE STARCH MICROSPHERES AND ANGIOTENSIN-II IN THE MANIPULATION OF DRUG DELIVERY IN AN ANIMAL-MODEL OF COLORECTAL METASTASIS [J].