Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

被引：732

作者：

Qiu, Xiangguo ^{[1
]}

Wong, Gary ^{[1
,2
]}

Audet, Jonathan ^{[1
,2
]}

Bello, Alexander ^{[1
,2
]}

Fernando, Lisa ^{[1
]}

Alimonti, Judie B. ^{[1
]}

Fausther-Bovendo, Hugues ^{[1
,2
]}

Wei, Haiyan ^{[1
,3
]}

Aviles, Jenna ^{[1
]}

Hiatt, Ernie ^{[4
]}

Johnson, Ashley ^{[4
]}

Morton, Josh ^{[4
]}

Swope, Kelsi ^{[4
]}

Bohorov, Ognian ^{[5
]}

Bohorova, Natasha ^{[5
]}

Goodman, Charles ^{[5
]}

Kim, Do ^{[5
]}

Pauly, Michael H. ^{[5
]}

Velasco, Jesus ^{[5
]}

Pettitt, James ^{[6
]}

Olinger, Gene G. ^{[6
]}

Whaley, Kevin ^{[5
]}

Xu, Bianli ^{[3
]}

Strong, James E. ^{[1
,2
,7
]}

Zeitlin, Larry ^{[5
]}

Kobinger, Gary P. ^{[1
,2
,8
,9
]}

机构：

[1] Publ Hlth Agcy Canada, Natl Lab Zoonot Dis & Special Pathogens, Winnipeg, MB R3E 3R2, Canada

[2] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0J9, Canada

[3] Henan Ctr Dis Control & Prevent, Inst Infect Dis, Zhengzhou 450012, Henan, Peoples R China

[4] Kentucky BioProc, Owensboro, KY 42301 USA

[5] Mapp Biopharmaceut Inc, San Diego, CA 92121 USA

[6] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA

[7] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB R3A 1S1, Canada

[8] Univ Manitoba, Dept Immunol, Winnipeg, MB R3E 0T5, Canada

[9] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

NATURE | 2014年 / 514卷 / 7520期

基金：

美国国家卫生研究院;

关键词：

POSTEXPOSURE PROTECTION; MEDIATED PROTECTION; HEMORRHAGIC-FEVER; ANTIBODIES; INFECTION; CHALLENGE;

D O I：

10.1038/nature13777

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Without an approved vaccine or treatments, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These approaches, however, have yet to end the 2014 outbreak of Ebola after its prolonged presence in West Africa. Here we show that a combination of monoclonal antibodies (ZMapp), optimized from two previous antibody cocktails, is able to rescue 100% of rhesus macaques when treatment is initiated up to 5 days post-challenge. High fever, viraemia and abnormalities in blood count and blood chemistry were evident in many animals before ZMapp intervention. Advanced disease, as indicated by elevated liver enzymes, mucosal haemorrhages and generalized petechia could be reversed, leading to full recovery. ELISA and neutralizing antibody assays indicate that ZMapp is cross-reactive with the Guinean variant of Ebola. ZMapp exceeds the efficacy of any other therapeutics described so far, and results warrant further development of this cocktail for clinical use.

引用

页码：47 / +

页数：15

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