New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity:: Taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities

被引：59

作者：

Dekker, KA

Inagaki, T

Gootz, TD

Huang, LH

Kojima, Y

Kohlbrenner, WE

Matsunaga, Y

McGuirk, PR

Nomura, E

Sakakibara, T

Sakemi, S

Suzuki, Y

Yamauchi, Y

Kojima, N

机构：

[1] Pfizer Pharmaceut Inc, Div Cent Res, Aichi 47023, Japan

[2] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 02期

关键词：

D O I：

10.7164/antibiotics.51.145

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activity when tested against a panel of other microorganisms.

引用

页码：145 / 152

页数：8

共 16 条

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