Cytokines in the human ovary:: Presence in follicular fluid and correlation with leukotriene B4

被引：22

作者：

Bili, H ^{[1
]}

Tarlatzis, BC ^{[1
]}

Daniilidis, M ^{[1
]}

Fleva, A ^{[1
]}

Bontis, J ^{[1
]}

Tourkantonis, A ^{[1
]}

Mantalenakis, S ^{[1
]}

机构：

[1] Aristotelian Univ Salonika, Dept Obstet & Gynecol 1, GR-54006 Salonika, Greece

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1998年 / 15卷 / 02期

关键词：

interleukin-1; alpha; interleukin-2; tumor necrosis factor-alpha; leukotriene B-4; human follicular fluid;

D O I：

10.1007/BF02766833

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: This study was undertaken to correlate the follicular levels of interleukin (IL)-1 alpha, IL-2, tumor necrosis factor-alpha (TNF-alpha), and leukotriene (LT) B-4 With oocyte maturity, fertilization, and achievement of pregnancy. Methods: The material was obtained from 22 women undergoing IVF, 8 of whom became pregnant and 14 of whom did not. Results: All of the studied cytokines and LT Bq were found in follicular fluids, but there were no significant differences according to oocyte maturity, fertilization, embryo quality, and achievement of pregnancy. On the other hand, a significant positive correlation was found between IL-1 alpha and TNF-alpha, IL-1 alpha, and LT B-4 as well as between TNF-alpha and LT B-4 in follicular fluids with subsequently fertilized oocytes. Conclusions: It seems that IL-1 alpha, TNF-alpha and LT B-4 may take part in the process of follicle wall degradation, and their follicular correlations may suggest more optimal follicular and oocyte development and maturation.

引用

页码：93 / 98

页数：6

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