N,N-dimethyldioncophyllinium A iodide: Synthesis, stereoanalysis, and antimalarial activity of the first N-quaternary naphthylisoquinolinium salt

被引：4

作者：

Bringmann, G

Ochse, M

Schaffer, M

God, R

Walter, R

Francois, G

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Inst Trop Med Prince Leopold, B-2000 Antwerp, Belgium

来源：

PLANTA MEDICA | 1997年 / 63卷 / 06期

关键词：

Ancistrocladaceae; Dioncophyllaceae; naphthylisoquinoline alkaloids; N-quaternary isoquinolinium salts; oxidative degradation; stereoanalysis; antimalarial activity; Plosmodium falciparum;

D O I：

10.1055/s-2006-957760

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The first synthesis of an N-quaternary salt of a naphthylisoquinoline alkaloid, N,N-dimethyldioncophyllinium A iodide, is described, For this potential natural product, a degradative procedure for the unambiguous stereoanalysis of the stereogenic centers has been elaborated. It shows enhanced antiplasmodial activity in vitro towards Plasmodium falciparum erythrocytic forms, as compared to its less methylated precursors.

引用

页码：544 / 547

页数：4

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