Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa

被引：63

作者：

Matsuda, Hisashi ^{[1
]}

Yoshida, Kazutoshi ^{[1
]}

Miyagawa, Katsutoshi ^{[1
]}

Asao, Yasunobu ^{[1
]}

Takayama, Saya ^{[1
]}

Nakashirna, Souichi ^{[1
]}

Xu, Fengming ^{[1
]}

Yoshikawa, Masayuki ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 03期

关键词：

rotenoids; anti-invasion; anti-proliferation; differentiation-inducin2; activity; HT1080; U937; HL-60;

D O I：

10.1016/j.bmc.2006.09.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Principal rotenoids (deguelin, tephrosin, rotenone, and 12a-hydroxyrotenone) (3-30 mu M) isolated from the stems of Erycibe expansa significantly inhibited invasion of human fibrosarcoma HT1080 cells through Matrigel-coated filters and release of proMMPs-2 and 9. In addition, deguelin and tephrosin showed differentiation-inducing activity in human promyelocytic leukemia HL-60 cells. Furthermore, effects of various constituents isolated from the ethyl acetate-soluble fraction on proliferation of human leukemia U937 cells were examined. As a result, most of isoflavones and several flavans as well as rotenoids showed moderate or substantial anti -proliferative activities. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1539 / 1546

页数：8

共 15 条

[1] Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway [J].