T-cell subsets: Transcriptional control in the Th1/Th2 decision

被引：56

作者：

Rincon, M

Flavell, RA

机构：

[1] UNIV VERMONT,DEPT MED,BURLINGTON,VT 05405

[2] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06520

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 11期

关键词：

D O I：

10.1016/S0960-9822(06)00368-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcriptional mechanisms in CD4(+) T cells and antigen-presenting cells determine the activation or differentiation of Th1 and Th2 helper cell subsets, and also form attractive targets for therapeutic intervention in the balance of Th1/Th2 responses. (C) Current Biology Ltd ISSN 0960-9822.

引用

页码：R729 / R732

页数：4

共 26 条

[1] Induction of TH1 and TH2 CD4+ T cell responses: The alternative approaches
Constant, SL
Bottomly, K
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 : 297 - 322
[2] DAVYDOV IV, 1995, J IMMUNOL, V155, P5273
[3] GORHAM JD, 1996, P NATL ACAD SCI USA, V93, P22
[4] The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
Ho, IC
Hodge, MR
Rooney, JW
Glimcher, LH
[J]. CELL, 1996, 85 (07) : 973 - 983
[5] Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice
Hodge, MR
Ranger, AM
delaBrousse, FC
Hoey, T
Grusby, MJ
Glimcher, LH
[J]. IMMUNITY, 1996, 4 (04) : 397 - 405
[6] REQUIREMENT FOR TRANSCRIPTION FACTOR IRF-1 IN NO SYNTHASE INDUCTION IN MACROPHAGES
KAMIJO, R
HARADA, H
MATSUYAMA, T
BOSLAND, M
GERECITANO, J
SHAPIRO, D
LE, J
KOH, SI
KIMURA, T
GREEN, SJ
MAK, TW
TANIGUCHI, T
VILCEK, J
[J]. SCIENCE, 1994, 263 (5153) : 1612 - 1615
[7] Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
Kaplan, MH
Schindler, U
Smiley, ST
Grusby, MJ
[J]. IMMUNITY, 1996, 4 (03) : 313 - 319
[8] INVOLVEMENT OF THE IRF-1 TRANSCRIPTION FACTOR IN ANTIVIRAL RESPONSES TO INTERFERONS
KIMURA, T
NAKAYAMA, K
PENNINGER, J
KITAGAWA, M
HARADA, H
MATSUYAMA, T
TANAKA, N
KAMIJO, R
VILCEK, J
MAK, TW
TANIGUCHI, T
[J]. SCIENCE, 1994, 264 (5167) : 1921 - 1924
[9] T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6
Kubo, M
Ransom, J
Webb, D
Hashimoto, Y
Tada, T
Nakayama, T
[J]. EMBO JOURNAL, 1997, 16 (13) : 4007 - 4020
[10] Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo
Lohoff, M
Ferrick, D
Mittrucker, HW
Duncan, GS
Bischof, S
Rollinghoff, M
Mak, TW
[J]. IMMUNITY, 1997, 6 (06) : 681 - 689

← 1 2 3 →