RECQL5 helicase: Connections to DNA recombination and RNA polymerase II transcription

被引：23

作者：

Aygun, Ozan ^{[1
]}

Svejstrup, Jesper Q. ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Clare Hall Labs, Canc Res UK London Res Inst, Mechanisms Transcript Lab, S Mimms EN6 3LD, Herts, England

来源：

DNA REPAIR | 2010年 / 9卷 / 03期

关键词：

REPLICATION FORK PROGRESSION; MAMMALIAN MEDIATOR COMPLEX; CARBOXYL-TERMINAL DOMAIN; SACCHAROMYCES-CEREVISIAE; HUMAN RECQ5-BETA; HOMOLOGOUS RECOMBINATION; FAMILY HELICASES; MITOTIC RECOMBINATION; HISTONE H3; CELL-CYCLE;

D O I：

10.1016/j.dnarep.2009.12.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The RecQ family of helicases are traditionally viewed as recombination factors, important for maintaining genome stability. RECQL5 is unique among these proteins in being associated with RNA polymerase II, the enzyme responsible for transcribing all protein-encoding genes in eukaryotes. Here, we describe the possible implications of recent studies and discuss models for RECQL5 function. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：345 / 353

页数：9

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