Sialoglycoprotein and carbohydrate complexes in chromium toxicity

被引：54

作者：

Codd, R ^{[1
]}

Irwin, JA ^{[1
]}

Lay, PA ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Ctr Heavy Met Res, Sydney, NSW 2006, Australia

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/S1367-5931(03)00017-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromium(VI) compounds are amongst the most widely encountered industrial carcinogens and are of increasing concern with respect to environmental exposure. Sialoglycoproteins and carbohydrates play a crucial role in stabilizing oxoCr(V) intermediates, which are produced by extracellular and intracellular reduction of chromium(VI). Recent research has addressed the molecular characterization of oxoCr(V)-sialoglycoprotein and -carbohydrate complexes and the roles that these species may play in Cr(VI) metabolism and carcinogenesis. Particular highlights include the role of oxoCr(V) complexes of extracellular sialoglycoproteins, intracellular D-glucose, and related species and their potential roles in Cr(VI)-induced genotoxicity.

引用

页码：213 / 219

页数：7

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