Facile production of mono-substituted urea side chains in solid phase peptide synthesis

被引：9

作者：

Diss, Maria L. ^{[1
]}

Kennan, Alan J. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

BIOPOLYMERS | 2007年 / 86卷 / 04期

关键词：

peptide synthesis; urea; solid phase;

D O I：

10.1002/bip.20737

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A method is reported for the straightforward generation of urea-containing peptides during Boc solid phase peptide synthesis. Primary amine side chains are converted to mono-alkyl ureas in two steps via an intermediate p-nitrophenyl carbamate. Use of p-methoxybenzyl amine as an ammonia equivalent affords mono-alkyl final products from standard resin cleavage methods, without the need for additional steps. The reaction is highly efficient and applicable to variable length side chains and peptides. (c) 2007 Wiley Periodicals, Inc.

引用

页码：276 / 281

页数：6

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