Small RNAs Guide Hematopoietic Cell Differentiation and Function

被引：57

作者：

Navarro, Francisco

Lieberman, Judy ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Immune Dis Inst, Childrens Hosp Boston, Boston, MA 02115 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 184卷 / 11期

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; MICRORNA EXPRESSION; NEGATIVE REGULATOR; MIRNA EXPRESSION; MATURE MICRORNA; TRANSGENIC MICE; T-CELLS; B-CELLS;

D O I：

10.4049/jimmunol.0902567

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MicroRNAs (miRNAs) are key regulators of gene expression that help direct normal differentiation and malignant transformation of hematopoietic cells. This review summarizes our current knowledge of how miRNAs function in normal and malignant hematopoiesis and how miRNAs might be applied for disease treatment. The Journal of Immunology, 2010, 184: 5939-5947.

引用

页码：5939 / 5947

页数：9

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