Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches

被引：141

作者：

Cevenini, E. ^{[3
,4
]}

Caruso, C. ^{[1
]}

Candore, G. ^{[1
]}

Capri, M. ^{[3
,4
]}

Nuzzo, D. ^{[2
]}

Duro, G. ^{[2
]}

Rizzo, C. ^{[1
]}

Colonna-Romano, G. ^{[1
]}

Lio, D. ^{[1
]}

Di Carlo, D. ^{[1
]}

Palmas, M. G. ^{[3
,4
]}

Scurti, M. ^{[3
,4
]}

Pini, E. ^{[3
,4
]}

Franceschi, C. ^{[3
,4
]}

Vasto, S. ^{[1
]}

机构：

[1] Univ Palermo, Dept Pathobiol & Biomed Methodol, Immunosenescence Unit, I-90134 Palermo, Italy

[2] CNR, IBIM, Palermo, Italy

[3] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

[4] Univ Bologna, CIG Interdepartmental Ctr L Galvani Integrated St, I-40126 Bologna, Italy

来源：

CURRENT PHARMACEUTICAL DESIGN | 2010年 / 16卷 / 06期

关键词：

Ageing; age-related diseases; immunosenescence; inflammation; GROWTH-FACTOR-I; CD8(+) T-CELLS; CYTOMEGALOVIRUS-INFECTION; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; MUSCLE STRENGTH; IMMUNE-SYSTEM; EVOLUTIONARY PERSPECTIVE; INFLUENZA VACCINATION; MEDITERRANEAN DIET;

D O I：

10.2174/138161210790883840

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A typical feature of ageing is a chronic, low-grade inflammation characterized by a general increase in the production of pro-inflammatory cytokines and inflammatory markers ("inflamm-ageing"). This status may slowly damage one or several organs, especially when unfavorable genetic polymorphisms and epigenetic alterations are concomitant, leading to an increased risk of frailty together with the onset of age-related chronic diseases. The contribution of different tissues (adipose tissue, muscle), organs (brain, liver), immune system and ecosystems (gut microbiota) to age-related inflammation ("inflamm-ageing") will be discussed in this review in the context of its onset/progression leading to site-restricted and systemic effects. Moreover, some of the possible strategies and therapies to counteract the different sources of molecular mediators which lead to the age-related inflammatory phenotype will be presented.

引用

页码：609 / 618

页数：10

共 142 条

[81] Melton LJ, 2000, J AM GERIATR SOC, V48, P625
[82] Zinc and immunoresistance to infection in aging: new biological tools
Mocchegiani, E
Muzzioli, M
Giacconi, R
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (06) : 205 - 208
[83] Evidence that vitamin D3 reverses age-related inflammatory changes in the rat hippocampus
Moore, ME
Piazza, A
McCartney, Y
Lynch, MA
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2005, 33 : 573 - 577
[84] Differences in fecal microbiota in different European study populations in relation to age, gender, and country:: A cross-sectional study
Mueller, S
Saunier, K
Hanisch, C
Norin, E
Alm, L
Midtvedt, T
Cresci, A
Silvi, S
Orpianesi, C
Verdenelli, MC
Clavel, T
Koebnick, C
Zunft, HJF
Doré, J
Blaut, M
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (02) : 1027 - 1033
[85] Renewing the T cell repertoire to arrest autoimmune aggression
Muraro, PA
Douek, DC
[J]. TRENDS IN IMMUNOLOGY, 2006, 27 (02) : 61 - 67
[86] Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
Musarò, A
McCullagh, K
Paul, A
Houghton, L
Dobrowolny, G
Molinaro, M
Barton, ER
Sweeney, HL
Rosenthal, N
[J]. NATURE GENETICS, 2001, 27 (02) : 195 - 200
[87] Gut microorganisms, mammalian metabolism and personalized health care
Nicholson, JK
Holmes, E
Wilson, ID
[J]. NATURE REVIEWS MICROBIOLOGY, 2005, 3 (05) : 431 - 438
[88] EXERCISE, INFECTION, AND IMMUNITY
NIEMAN, DC
[J]. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 1994, 15 : S131 - S141
[89] Nieto-Vazquez Iria, 2008, Archives of Physiology and Biochemistry, V114, P183, DOI 10.1080/13813450802181047
[90] Gastrointestinal tract in liver disease: which organ is sick?
Norman, Kristina
Pirlich, Matthias
[J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2008, 11 (05) : 613 - 619

← 4 5 6 7 8 9 10 11 12 13 →