New C(4)-functionalized colchicine derivatives by a versatile multicomponent electrophilic aromatic substitution

被引：8

作者：

Bensel, N

Lagnoux, D

Niggli, V

Wartmann, M

Reymond, JL

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

[2] Univ Bern, Inst Pathol, CH-3010 Bern, Switzerland

[3] Novartis Inst Biomed Res, CH-4002 Basel, Switzerland

[4] Novartis Inst Oncol Res, CH-4002 Basel, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2004年 / 87卷 / 09期

关键词：

D O I：

10.1002/hlca.200490203

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electrophilic alkylation of colchicine at C(4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes and carboxylic acids or amides in H2SO4. A series of new derivatives were obtained and evaluated for their antiproliferative effect towards various tumor cell lines, and their stimulatory effect on the development of polarity in human neutrophils.

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页码：2266 / 2272

页数：7

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