Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes

被引：147

作者：

Barski, Artem ^{[1
]}

Chepelev, Iouri ^{[1
]}

Liko, Dritan ^{[2
]}

Cuddapah, Suresh ^{[1
]}

Fleming, Alastair B. ^{[2
]}

Birch, Joanna ^{[2
]}

Cui, Kairong ^{[1
]}

White, Robert J. ^{[2
]}

Zhao, Keji ^{[1
]}

机构：

[1] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

[2] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2010年 / 17卷 / 05期

基金：

美国国家卫生研究院;

关键词：

POLYMERASE-III; CHROMATIN; ACTIVATION; METHYLATIONS; ELEMENTS;

D O I：

10.1038/nsmb.1806

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin landscape of Pol III-transcribed genes resembles that of Pol II templates in many ways, although there are also clear differences. Our analysis also uncovered an entirely unexpected phenomenon: namely, that Pol II is present at the majority of genomic loci that are bound by Pol III.

引用

收藏

页码：629 / U132

页数：7

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