Meiotic sex chromosome inactivation

被引:496
作者
Turner, James M. A. [1 ]
机构
[1] Natl Inst Med Res, MRC, Div Stem Cell Biol & Dev Genet, London NW7 1AA, England
来源
DEVELOPMENT | 2007年 / 134卷 / 10期
基金
英国医学研究理事会;
关键词
D O I
10.1242/dev.000018
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
X chromosome inactivation is most commonly studied in the context of female mammalian development, where it performs an essential role in dosage compensation. However, another form of X-inactivation takes place in the male, during spermatogenesis, as germ cells enter meiosis. This second form of X-inactivation, called meiotic sex chromosome inactivation (MSCI) has emerged as a novel paradigm for studying the epigenetic regulation of gene expression. New studies have revealed that MSCI is a special example of a more general mechanism called meiotic silencing of unsynapsed chromatin (MSUC), which silences chromosomes that fail to pair with their homologous partners and, in doing so, may protect against aneuploidy in subsequent generations. Furthermore, failure in MSCI is emerging as an important etiological factor in meiotic sterility.
引用
收藏
页码:1823 / 1831
页数:9
相关论文
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