Fluorous chiral bisoxazolines. Synthesis and applications to an asymmetric allylic alkylation

被引：29

作者：

Bayardon, J ^{[1
]}

Sinou, D ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, CPE, Lab Synthese Asymetr, F-69622 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 07期

关键词：

asymmetric alkylation; fluorous bisoxazolines; palladium catalyst;

D O I：

10.1016/S0040-4039(02)02851-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The easily accessible fluorous bisoxazolines 3a-b bearing two fluorous ponytails are efficient ligands in the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylprop-2-enyl acetate with carbonucleophiles in benzotrifluoride or CH2Cl2, enantioselectivities of up to 95% being obtained. The ligand is easily separated from the reaction mixture by simple extraction with a fluorous solvent. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1449 / 1451

页数：3

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