Mechanisms and consequences of activation of protein kinase B/Akt

被引：1212

作者：

Downward, J ^{[1
]}

机构：

[1] Imperial Canc Res Fund, London WC2A 3PX, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(98)80149-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein ki nase B (PKB)/Akt is a growth-factor-regulated serine/threonine kinase which contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, and also mediates a number of metabolic effects of insulin. (C) Current Biology Ltd ISSN 0955-0674.

引用

页码：262 / 267

页数：6

共 51 条

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