4-aryldihydropyrimidines via the Biginelli condensation: Aza-analogs of nifedipine-type calcium channel modulators

被引：175

作者：

Kappe, CO ^{[1
]}

机构：

[1] Graz Univ, Inst Organ Chem, A-8010 Graz, Austria

来源：

MOLECULES | 1998年 / 3卷 / 01期

关键词：

Biginelli reaction; dihydropyridines; dihydropyrimidines; calcium channel modulators;

D O I：

10.3390/30100001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent results from the author's laboratory in the area of dihydropyrimidine chemistry are summarized.

引用

页码：1 / 9

页数：9

共 87 条

[61]

REMMENIKOV GY, 1991, KHIM FARM ZH, V25, P35

[62]

REMNENIKOV GY, 1993, KHIM GETEROTSIL SOED, P1398

[63]

ROBINETT LD, 1996, 211 NAT M AM CHEM SO

[64] DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .4. BASIC 3-SUBSTITUTED-4-ARYL-1,4-DIHYDROPYRIMIDINE-5-CARBOXYLIC ACID-ESTERS - POTENT ANTIHYPERTENSIVE AGENTS [J].

ROVNYAK, GC ;

ATWAL, KS ;

HEDBERG, A ;

KIMBALL, SD ;

MORELAND, S ;

GOUGOUTAS, JZ ;

OREILLY, BC ;

SCHWARTZ, J ;

MALLEY, MF .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (17) :3254-3263

[65] CALCIUM-ENTRY BLOCKERS AND ACTIVATORS - CONFORMATIONAL AND STRUCTURAL DETERMINANTS OF DIHYDROPYRIMIDINE CALCIUM-CHANNEL MODULATORS [J].

ROVNYAK, GC ;

KIMBALL, SD ;

BEYER, B ;

CUCINOTTA, G ;

DIMARCO, JD ;

GOUGOUTAS, J ;

HEDBERG, A ;

MALLEY, M ;

MCCARTHY, JP ;

ZHANG, RA ;

MORELAND, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (01) :119-129

[66]

SAR CP, 1994, ACH-MODELS CHEM, V131, P363

[67]

SAUSINS A, 1988, HETEROCYCLES, V27, P269

[68]

SAUSINS A, 1988, HETEROCYCLES, V27, P291

[69]

SCHLEIFER KJ, 1995, PHARM PHARM LETT, V5, P162

[70]

Schulte M, 1997, NACHR CHEM TECH LAB, V45, P487

← 1 2 3 4 5 6 7 8 9 →