4-aryldihydropyrimidines via the Biginelli condensation: Aza-analogs of nifedipine-type calcium channel modulators

被引:175
作者
Kappe, CO [1 ]
机构
[1] Graz Univ, Inst Organ Chem, A-8010 Graz, Austria
关键词
Biginelli reaction; dihydropyridines; dihydropyrimidines; calcium channel modulators;
D O I
10.3390/30100001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent results from the author's laboratory in the area of dihydropyrimidine chemistry are summarized.
引用
收藏
页码:1 / 9
页数:9
相关论文
共 87 条
[81]   Fluorous synthesis: Fluorous protocols for the Ugi and Biginelli multicomponent condensations [J].
Studer, A ;
Jeger, P ;
Wipf, P ;
Curran, DP .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (09) :2917-2924
[82]  
Sudan S, 1996, J INDIAN CHEM SOC, V73, P431
[83]   SYNTHESIS OF 3,4-DIHYDRO-2(1H)-PYRIMIDINONES AND MECHANISM OF BIGINELLI REACTION [J].
SWEET, F ;
FISSEKIS, JD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (26) :8741-8749
[84]  
Triggle D. J., 1995, CHEMTRACTS ORG CHEM, V8, P191
[85]  
vandenEynde JJ, 1997, HETEROCYCLES, V45, P1967
[86]   A SOLID-PHASE PROTOCOL OF THE BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS SUITABLE FOR COMBINATORIAL CHEMISTRY [J].
WIPF, P ;
CUNNINGHAM, A .
TETRAHEDRON LETTERS, 1995, 36 (43) :7819-7822
[87]  
ZAVYALOV SI, 1992, KHIM FARM ZH+, V26, P116