Progress toward the clinical application of patient-specific pluripotent stem cells

被引：269

作者：

Kiskinis, Evangelos ^{[1
]}

Eggan, Kevin ^{[1
]}

机构：

[1] Harvard Univ, Stowers Med Inst, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 01期

关键词：

HUMAN SOMATIC-CELLS; MOTOR-NEURONS; HUMAN FIBROBLASTS; GENE-EXPRESSION; GENERATION; MOUSE; INDUCTION; MURINE; MODEL; MICE;

D O I：

10.1172/JCI40553

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Induced pluripotent stem (iPS) cells are generated by epigenetic reprogramming of somatic cells through the exogenous expression of transcription factors. These cells, just like embryonic stem cells, are likely to have a major impact on regenerative medicine, because they self-renew and retain the potential to be differentiated into all cell types of the human body. In this Review, we describe the current state of iPS cell technology, including approaches by which they are generated and what is known about their biology, and discuss the potential applications of these cells for disease modeling, drug discovery, and, eventually, cell replacement therapy.

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页码：51 / 59

页数：9

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