Sample size formula for proportional hazards modelling of competing risks

被引：77

作者：

Latouche, A ^{[1
]}

Porcher, R ^{[1
]}

Chevret, S ^{[1
]}

机构：

[1] Univ Paris 07, Dept Biostat & Informat Med, Hop St Louis, INSERM,ERM 321, F-75475 Paris 10, France

来源：

STATISTICS IN MEDICINE | 2004年 / 23卷 / 21期

关键词：

competing risks; sample size; subdistribution hazard; cumulative incidence;

D O I：

10.1002/sim.1915

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To test the effect of a therapeutic or prognostic factor on the occurrence of a particular cause of failure in the presence of other causes, the interest has shifted in some studies from the modelling of the cause-specific hazard to that of the subdistribution hazard. We present approximate sample size formulas for the proportional hazards modelling of competing risk subdistribution, considering either independent or correlated covariates. The validity of these approximate formulas is investigated through numerical simulations. Two illustrations are provided, a randomized clinical trial, and a prospective prognostic study. Copyright (C) 2004 John Wiley Sons, Ltd.

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收藏

页码：3263 / 3274

页数：12

相关论文

共 24 条

[11]

Kalbfleisch JD., 2011, STAT ANAL FAILURE TI

[12]

KLEIN JP, 2003, REGRESSION MODELING

[13] APPLICATIONS OF CRUDE INCIDENCE CURVES [J].

KORN, EL ;

DOREY, FJ .

STATISTICS IN MEDICINE, 1992, 11 (06) :813-829

[14] EVALUATION OF SAMPLE-SIZE AND POWER FOR ANALYSES OF SURVIVAL WITH ALLOWANCE FOR NONUNIFORM PATIENT ENTRY, LOSSES TO FOLLOW-UP, NONCOMPLIANCE, AND STRATIFICATION [J].

LACHIN, JM ;

FOULKES, MA .

BIOMETRICS, 1986, 42 (03) :507-519

[15] INFERENCE FOR EVENTS WITH DEPENDENT RISKS IN MULTIPLE END-POINT STUDIES [J].

PEPE, MS .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1991, 86 (415) :770-778

[16] KAPLAN-MEIER, MARGINAL OR CONDITIONAL-PROBABILITY CURVES IN SUMMARIZING COMPETING RISKS FAILURE TIME DATA [J].

PEPE, MS ;

MORI, M .

STATISTICS IN MEDICINE, 1993, 12 (08) :737-751

[17] Dealing with competing risks: testing covariates and calculating sample size [J].

Pintilie, M .

STATISTICS IN MEDICINE, 2002, 21 (22) :3317-3324

[18] ANALYSIS OF FAILURE TIMES IN PRESENCE OF COMPETING RISKS [J].

PRENTICE, RL ;

KALBFLEISCH, JD ;

PETERSON, AV ;

FLOURNOY, N ;

FAREWELL, VT ;

BRESLOW, NE .

BIOMETRICS, 1978, 34 (04) :541-554

[19] Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation [J].

Rocha, V ;

Franco, RF ;

Porcher, R ;

Bittencourt, H ;

Silva, WA ;

Latouche, A ;

Devergie, A ;

Espérou, H ;

Ribaud, P ;

Socié, G ;

Zago, MA ;

Gluckman, E .

BLOOD, 2002, 100 (12) :3908-3918

[20] Induction of labour with a viable infant:: a randomised clinical trial comparing intravaginal misoprostol and intravaginal dinoprostone [J].

Rozenberg, P ;

Chevret, S ;

Goffinet, F ;

Durand-Zaleski, I ;

Ville, Y ;

Vayssière, C ;

Roberto, A ;

Lahna, Z ;

Nisand, I ;

Fisch, C ;

Chaumet-Riffaud, P ;

Chastang, C .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2001, 108 (12) :1255-1262