Myeloproliferative neoplasms: Morphology and clinical practice

被引：33

作者：

Barbui, Tiziano ^{[1
]}

Thiele, Juergen ^{[2
]}

Vannucchi, Alessandro M. ^{[3
]}

Tefferi, Ayalew ^{[4
]}

机构：

[1] Papa Giovanni XXIII Hosp, Res Fdn, Bergamo, Italy

[2] Univ Cologne, Inst Pathol, Joseph Stelzmann Str 9, Cologne, Germany

[3] Univ Florence, Dept Expt & Clin Med, Florence, Italy

[4] Mayo Clin, Div Hematol, Rochester, MN USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2016年 / 91卷 / 04期

关键词：

BONE-MARROW FIBROSIS; CHRONIC IDIOPATHIC MYELOFIBROSIS; INTERNATIONAL WORKING GROUP; ESSENTIAL THROMBOCYTHEMIA; POLYCYTHEMIA-VERA; REFRACTORY-ANEMIA; RINGED SIDEROBLASTS; DIAGNOSTIC-CRITERIA; HISTOLOGICAL CRITERIA; BLAST-TRANSFORMATION;

D O I：

10.1002/ajh.24288

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In myeloproliferative neoplasms (MPNs), controversy persists regarding the usefulness and reproducibility of bone marrow (BM) features. Disagreements concerning the WHO classification are mainly focused on the discrimination between essential thrombocythemia (ET) and prefibrotic/early primary myelofibrosis (prePMF) and prodromal polycythemia vera (PV). Criticism mostly refers to lack of standardization of distinctive BM features precluding correct morphological pattern recognition. The distinction between WHO-defined ET and prePMF is not trivial because outcome is significantly worse in prePMF. Morphology was generally considered to be non-specific for the diagnosis of PV. Recent studies have revealed under-diagnosis of morphologically and biologically consistent PV. Am. J. Hematol. 91:430-433, 2016. (c) 2015 Wiley Periodicals, Inc.

引用

页码：430 / 433

页数：4

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