Toxin structure: Part of a hole?

被引：44

作者：

Bayley, H

机构：

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(06)00399-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the monomeric form of perfringolysin O solved by X-ray crystallography has been used to model the very large transmembrane pore formed when this bacterial protein toxin assembles in cholesterol-containing membranes. The structure is a notable advance, but it may not provide the whole story.

引用

页码：R763 / R767

页数：5

共 23 条

[1] Alouf J.E., 1991, SOURCEBOOK BACTERIAL, P147
[2] [Anonymous], 1996, Reviews in Medical Microbiology
[3] BHAKDI S, 1985, INFECT IMMUN, V47, P52
[4] BHAKDI S, 1994, MED MICROBIOL IMMUN, V183, P119, DOI 10.1007/BF00196048
[5] COMPLEMENT ACTIVATION AND ATTACK ON AUTOLOGOUS CELL-MEMBRANES INDUCED BY STREPTOLYSIN-O
BHAKDI, S
TRANUMJENSEN, J
[J]. INFECTION AND IMMUNITY, 1985, 48 (03) : 713 - 719
[6] Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous beta-sheet helix
Blake, C
Serpell, L
[J]. STRUCTURE, 1996, 4 (08) : 989 - 998
[7] Functional analysis of pneumolysin by use of monoclonal antibodies
delosToyos, JR
Mendez, FJ
Aparicio, JF
Vazquez, F
Suarez, MD
Fleites, A
Hardisson, C
Morgan, PJ
Andrew, PW
Mitchell, TJ
[J]. INFECTION AND IMMUNITY, 1996, 64 (02) : 480 - 484
[8] BINDING-SITES FOR CHOLESTEROL ON CA2+-ATPASE STUDIED BY USING A CHOLESTEROL-CONTAINING PHOSPHOLIPID
DING, J
STARLING, AP
EAST, JM
LEE, AG
[J]. BIOCHEMISTRY, 1994, 33 (16) : 4974 - 4979
[9] Channel-forming toxins: Tales of transformation
Gouaux, E
[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 1997, 7 (04) : 566 - 573
[10] HAMMAN BD, 1997, CELL, V89, P635

← 1 2 3 →