Toward the development of α1a adrenergic receptor antagonists

被引:36
作者
Bock, MG [1 ]
Patane, MA [1 ]
机构
[1] Merck Res Labs, West Point, PA 19486 USA
来源
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 35 | 2000年 / 35卷
关键词
D O I
10.1016/S0065-7743(00)35021-7
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:221 / 230
页数:10
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共 84 条
[71]  
SULLIVAN J, 1988, IDRUGS, V1, P652
[72]   New α1-adrenoceptor antagonist, JTH-601, shows more than 10 times higher affinity for human prostates than arteries [J].
Takahashi, M ;
Taniguchi, T ;
Murata, S ;
Okada, K ;
Moriyama, N ;
Yamazaki, S ;
Muramatsu, I .
JOURNAL OF UROLOGY, 1999, 161 (04) :1350-1354
[73]   URINARY FLOW-RATES IN PATIENTS WITH BENIGN PROSTATIC HYPERTROPHY FOLLOWING TREATMENT WITH ALFUZOSIN [J].
TEILLAC, P ;
DELAUCHECAVALLIER, MC ;
ATTALI, P .
BRITISH JOURNAL OF UROLOGY, 1992, 70 (01) :58-64
[74]  
Testa R, 1996, J PHARMACOL EXP THER, V277, P1237
[75]   THE ALPHA(1C)-ADRENOCEPTOR IN HUMAN PROSTATE - CLONING, FUNCTIONAL EXPRESSION, AND LOCALIZATION TO SPECIFIC PROSTATIC CELL-TYPES [J].
TSENGCRANK, J ;
KOST, T ;
GOETZ, A ;
HAZUM, S ;
ROBERSON, KM ;
HAIZLIP, J ;
GODINOT, N ;
ROBERTSON, CN ;
SAUSSY, D .
BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (08) :1475-1485
[76]   DISCOVERY OF ALPHA(1A)-ADRENERGIC RECEPTOR ANTAGONISTS BASED ON THE L-TYPE CA2+ CHANNEL ANTAGONIST NIGULDIPINE [J].
WETZEL, JM ;
MIAO, SW ;
FORRAY, C ;
BORDEN, LA ;
BRANCHEK, TA ;
GLUCHOWSKI, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (10) :1579-1581
[77]  
WHITFIELD HN, 1975, BRIT J UROL, V47, P823, DOI 10.1111/j.1464-410X.1975.tb04063.x
[78]   ALFUZOSIN - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN BENIGN PROSTATIC HYPERPLASIA [J].
WILDE, MI ;
FITTON, A ;
MCTAVISH, D .
DRUGS, 1993, 45 (03) :410-429
[79]   In vitro α1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α1A-adrenoceptor selective antagonists [J].
Williams, TJ ;
Blue, DR ;
Daniels, DV ;
Davis, B ;
Elworthy, T ;
Gever, JR ;
Kava, MS ;
Morgans, D ;
Padilla, F ;
Tassa, S ;
Vimont, RL ;
Chapple, CR ;
Chess-Williams, R ;
Eglen, RM ;
Clarke, DE ;
Ford, APDW .
BRITISH JOURNAL OF PHARMACOLOGY, 1999, 127 (01) :252-258
[80]   Design and synthesis of novel α1a adrenoceptor-selective antagonists.: 4.: Structure-activity relationship in the dihydropyrimidine series [J].
Wong, WC ;
Sun, WY ;
Lagu, B ;
Tian, D ;
Marzabadi, MR ;
Zhang, FQ ;
Nagarathnam, D ;
Miao, SW ;
Wetzel, JM ;
Peng, J ;
Forray, C ;
Chang, RSL ;
Chen, TB ;
Ransom, R ;
O'Malley, S ;
Broten, TP ;
Kling, P ;
Vyas, KP ;
Zhang, KY ;
Gluchowski, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (23) :4804-4813