Solid phase synthesis of benzamidine-derived sulfonamide libraries

被引：13

作者：

Kim, SW

Hong, CY

Koh, JS

Lee, EJ

Lee, K

机构：

[1] LG Chem Ltd, Biotech Res Inst, Taejon 305380, South Korea

[2] Korea Adv Inst Sci & Technol, Taejon 306701, South Korea

来源：

MOLECULAR DIVERSITY | 1998年 / 3卷 / 02期

关键词：

benzamidine-containing sulfonamide; solid phase synthesis; thrombin;

D O I：

10.1023/A:1009608400697

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using solid phase synthesis, a library has been constructed of benzamidine-derived sulfonamides which have strong inhibitory activity against blood coagulant thrombin. The library compounds were obtained in good yield and high purity.

引用

页码：133 / 136

页数：4

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