Quantum-dot-based immunofluorescent imaging of HER2 and ER provides new insights into breast cancer heterogeneity

被引：60

作者：

Chen, Chuang ^{[1
,2
,3
]}

Peng, Jun ^{[4
,5
]}

Xia, Heshun ^{[6
]}

Wu, Qiongshui ^{[7
]}

Zeng, Libo ^{[7
]}

Xu, Hao ^{[4
,5
]}

Tang, Hongwu ^{[4
,5
]}

Zhang, Zhiling ^{[4
,5
]}

Zhu, Xiaobo ^{[8
]}

Pang, Daiwen ^{[4
,5
]}

Li, Yan ^{[1
,2
,3
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp, Dept Oncol, Wuhan 430071, Peoples R China

[2] Hubei Key Lab Tumor Biol Behav, Wuhan 430071, Peoples R China

[3] Hubei Canc Clin Study Ctr, Wuhan 430071, Peoples R China

[4] Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, Peoples R China

[5] Wuhan Univ, State Key Lab Virol, Wuhan 430072, Peoples R China

[6] Hubei Canc Hosp, Dept Pathol, Wuhan 430079, Hubei, Peoples R China

[7] Wuhan Univ, Elect Informat Sch, Sci Instrument Engn Res Ctr, Wuhan 430072, Peoples R China

[8] Wuhan Jiayuan Quantum Dots Co Ltd, Wuhan 430074, Peoples R China

来源：

NANOTECHNOLOGY | 2010年 / 21卷 / 09期

关键词：

ESTROGEN-RECEPTOR; HEPATOCELLULAR-CARCINOMA; TISSUE MICROARRAYS; HORMONE-RECEPTORS; THERAPY; HER-2/NEU; IMMUNOHISTOCHEMISTRY; COEXPRESSION; TECHNOLOGY; RESISTANCE;

D O I：

10.1088/0957-4484/21/9/095101

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Breast cancer (BC) is a heterogeneous tumor, and better understanding of its heterogeneity is essential to improving treatment effect. Quantum dot (QD)-based immunofluorescent nanotechnology (QD-IHC) for molecular pathology has potential advantages in delineating tumor heterogeneity. This potential is explored in this paper by QD-IHC imaging of HER2 and ER. BC heterogeneity can be displayed more clearly and sensitively by QD-IHC than conventional IHC in BC tissue microarrays. Furthermore, the simultaneous imaging of ER and HER2 might help understand their interactions during the process of evolution of heterogeneous BC.

引用

页数：6

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