Recent trends in enzymatic conversion of cephalosporin C to 7-Aminocephalosporanic acid (7-ACA)

被引：40

作者：

Parmar, A

Kumar, H

Marwaha, SS

Kennedy, JF ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Res Lab Chem Carbohydrates & Prot, Birmingham Carbohydrate & Prot Technol Grp, Birmingham B15 2TT, W Midlands, England

[2] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India

[3] Sant Longowal Inst Engn & Technol, Dept Chem, Longowal 148106, India

[4] Punjabi Univ, Dept Biotechnol, Patiala 147002, Punjab, India

来源：

CRITICAL REVIEWS IN BIOTECHNOLOGY | 1998年 / 18卷 / 01期

关键词：

cephalosporin C; 7-Aminocephalosporanic acid (7-ACA); D-amino acid oxidase; Trigonopsis variabilis; Rhodotorula gracilis; GL-7ACA acylase;

D O I：

10.1080/0738-859891224194

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

7-Aminocephalosporanic acid (7-ACA) is the basic building block used in the synthesis of many important semisynthetic cephalosporin antibiotics that are of current interest in the biopharmaceutical industry with a share of about 29% of the estimated worldwide antibiotic market. This article describes the important recent developments for the biosynthesis of 7-Aminocephalosporanic acid (7-ACA) from cephalosporin C using the enzymatic route. Details of purification, stability, and immobilization of the enzymes used for this biotransformation are also described.

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页码：1 / 12

页数：12

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