The role of TRAF6 in signal transduction and the immune response

被引：133

作者：

Kobayashi, T ^{[1
]}

Walsh, MC ^{[1
]}

Choi, YW ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 14期

关键词：

TRAF6; Toll-like receptor; CD40; dendritic cells; innate immune response;

D O I：

10.1016/j.micinf.2004.09.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) family and TNF receptor (TNFR) superfamily are critical for regulating the function of antigen-presenting cells such as dendritic cells (DCs). It has been revealed that TNF receptor-associated factor 6 (TRAF6), a signaling adapter molecule common to the IL-1R/TLR family and TNFR superfamily, is important not only for DC maturation, cytokine production, and T cell stimulatory capacity of DCs in response to TLR ligands (e.g. lipopolysaccharide) or CD40 ligand, but also for the homeostasis of splenic DC subsets. (C) 2004 Elsevier SAS. All rights reserved.

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页码：1333 / 1338

页数：6

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