Synthesis of monoterpenic analogues of puupehenone and puupehedione

被引:22
作者
Barrero, AF [1 ]
Alvarez-Manzaneda, EJ [1 ]
Herrador, MM [1 ]
Valdivia, MV [1 ]
Chahboun, R [1 ]
机构
[1] Univ Granada, Fac Ciencias, Dept Quim Organ, E-18071 Granada, Spain
关键词
D O I
10.1016/S0040-4039(98)00216-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Compounds 7-8, monoterpenic analogues of the marine metabolites puupehenone (1) and puupehedione (2), were prepared from the easily available beta-cyclocitral (10) and the aryllithium derived from 11 and 12. 8 showed antitumoral activity 4-10 times higher than that for the natural products. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2425 / 2428
页数:4
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