In Vivo mouse imaging and spectroscopy in drug discovery

被引:86
作者
Beckmann, Nicolau
Kneuer, Rainer
Gremlich, Hans-Ulrich
Karmouty-Quintana, Harry
Ble, Francois-Xavier
Mueller, Matthias
机构
[1] Novartis Inst Biomed Res, Discovery Technol, CH-4002 Basel, Switzerland
[2] Novartis Inst Biomed Res, Models Dis Ctr, CH-4002 Basel, Switzerland
[3] Kings Coll London, Sackler Inst Pulm Pharmacol, London SE1 1UL, England
[4] Univ Strasbourg 1, Fac Pharm, F-67401 Illkirch Graffenstaden, France
关键词
bioluminescence; imaging; MRI; micro-PET; mouse; near-infrared fluorescence imaging; transgenic mice; ultrasound;
D O I
10.1002/nbm.1153
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Imaging modalities such as micro-computed tomography (micro-CT), micro-positron emission tomography (micro-PET), high-resolution MRI, optical imaging, and high-resolution ultrasound have become invaluable tools in preclinical pharmaceutical research. They can be used to non-invasively investigate, in vivo, rodent biology and metabolism, disease models, and pharmacokinetics and pharmacodynamics of drugs. The advantages and limitations of each approach usually determine its application, and therefore a small-rodent imaging laboratory in a pharmaceutical environment should ideally provide access to several techniques. In this paper we aim to illustrate how these techniques may be used to obtain meaningful information for the phenotyping of transgenic mice and for the analysis of compounds in murine models of disease. Copyright (C) 2007 John Wiley & Sons, Ltd.
引用
收藏
页码:154 / 185
页数:32
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