Frequency and phenotype of circulating Vα24/Vβ11 double-positive natural killer T cells during hepatitis C virus infection

被引：89

作者：

Lucas, M

Gadola, S

Meier, U

Young, NT

Harcourt, G

Karadimitris, A

Coumi, N

Brown, D

Dusheiko, G

Cerundolo, V

Klenerman, P

机构：

[1] Univ Oxford, Nuffield Dept Med, Weatherall Inst Mol Med, Oxford OX1 3SY, England

[2] John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England

[3] Royal Free Hosp, Ctr Hepatol, London NW3 2QG, England

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 03期

关键词：

D O I：

10.1128/JVI.77.3.2251-2257.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.

引用

收藏

页码：2251 / 2257

页数：7

相关论文

共 34 条

[21] CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection [J].

Motsinger, A ;

Haas, DW ;

Stanic, AK ;

Van Kaer, L ;

Joyce, S ;

Unutmaz, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (07) :869-879

[22]

Nuti S, 1998, EUR J IMMUNOL, V28, P3448, DOI 10.1002/(SICI)1521-4141(199811)28:11<3448::AID-IMMU3448>3.0.CO

[23]

2-5

[24]

Oishi Y, 2001, J RHEUMATOL, V28, P275

[25] CD4-CD8- T cells bearing invariant Vα24JαQ TCR α-chain are decreased in patients with atopic diseases [J].

Oishi, Y ;

Sakamoto, A ;

Kurasawa, K ;

Nakajima, H ;

Nakao, A ;

Nakagawa, N ;

Tanabe, E ;

Saito, Y ;

Iwamoto, I .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 119 (03) :404-411

[26] Selective loss of innate CD4+ Vα24 natural killer T cells in human immunodeficiency virus infection [J].

Sandberg, JK ;

Fast, NM ;

Palacios, EH ;

Fennelly, G ;

Dobroszycki, J ;

Palumbo, P ;

Wiznia, A ;

Grant, RM ;

Bhardwaj, N ;

Rosenberg, MG ;

Nixon, DF .

JOURNAL OF VIROLOGY, 2002, 76 (15) :7528-7534

[27] Requirement for natural killer T (NKT) cells in the induction of allograft tolerance [J].

Seino, K ;

Fukao, K ;

Muramoto, K ;

Yanagisawa, K ;

Takada, Y ;

Kakuta, S ;

Iwakura, Y ;

Van Kaer, L ;

Takeda, K ;

Nakayama, T ;

Taniguchi, M ;

Bashuda, H ;

Yagita, H ;

Okumura, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) :2577-2581

[28] NKT cells - conductors of tumor immunity? [J].

Smyth, MJ ;

Crowe, NY ;

Hayakawa, Y ;

Takeda, K ;

Yagita, H ;

Godfrey, DI .

CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (02) :165-171

[29] Cutting edge:: Analysis of human Vα24+CD8+ NK T cells activated by α-galactosylceramide-pulsed monocyte-derived dendritic cells [J].

Takahashi, T ;

Chiba, S ;

Nieda, M ;

Azuma, T ;

Ishihara, S ;

Shibata, Y ;

Juji, T ;

Hirai, H .

JOURNAL OF IMMUNOLOGY, 2002, 168 (07) :3140-3144

[30] Critical contribution of liver natural killer T cells to a murine model of hepatitis [J].

Takeda, K ;

Hayakawa, Y ;

Van Kaer, L ;

Matsuda, H ;

Yagita, H ;

Okumura, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5498-5503

← 1 2 3 4 →