Synthesis of the angiotensin-converting enzyme inhibitor (±)-A58365A

被引：18

作者：

Clive, DLJ ^{[1
]}

Coltart, DM ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 17期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(98)00384-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Crystalline (+/-)-A58365A (1), an inhibitor of angiotensin-converting enzyme, was synthesized by a process based on enyne radical cyclization (13a,b --> 14a,b). The starting material for this process was constructed by coupling the spiro lactone 6 with the amino acid 7, followed by elaboration into 13a,b. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2519 / 2522

页数：4

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