Why do we lack an effective vaccine against herpes simplex virus infections?

被引：30

作者：

Deshpande, SP ^{[1
]}

Kumaraguru, U ^{[1
]}

Rouse, BT ^{[1
]}

机构：

[1] Univ Tennessee, Dept Microbiol, Knoxville, TN 37996 USA

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 08期

关键词：

herpes simplex virus; immune response; vaccines;

D O I：

10.1016/S1286-4579(00)00339-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review discusses the possible causes for the lack of an effective antiherpes vaccine. Future prospects of vaccines based on the current knowledge of immune responses to herpes viruses are discussed. It is argued that vaccines capable of expanding CD8 T-cell memory responses should be the focus of future anti-herpes simplex virus research. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：973 / 978

页数：6

共 55 条

[1] HERPESVIRUSES - IMMUNE ESCAPE ARTISTS [J].

BANKS, TA ;

ROUSE, BT .

CLINICAL INFECTIOUS DISEASES, 1992, 14 (04) :933-941

[2] THE ESSENCE OF EPITOPES [J].

BARBER, LD ;

PARHAM, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1191-1194

[3] Herpes simplex virus vaccines [J].

Bernstein, DI ;

Stanberry, LR .

VACCINE, 1999, 17 (13-14) :1681-1689

[4]

Biron CA, 1999, CURR OPIN MICROBIOL, V2, P374

[5] Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity [J].

Blaney, JE ;

Nobusawa, E ;

Brehm, MA ;

Bonneau, RH ;

Mylin, LM ;

Fu, TM ;

Kawaoka, Y ;

Tevethia, SS .

JOURNAL OF VIROLOGY, 1998, 72 (12) :9567-9574

[6] GAMMA-INTERFERON EXPRESSION DURING ACUTE AND LATENT NERVOUS-SYSTEM INFECTION BY HERPES-SIMPLEX VIRUS TYPE-1 [J].

CANTIN, EM ;

HINTON, DR ;

CHEN, J ;

OPENSHAW, H .

JOURNAL OF VIROLOGY, 1995, 69 (08) :4898-4905

[7] EVOLUTION OF RECURRENT HERPES-SIMPLEX LESIONS - AN IMMUNOHISTOLOGIC STUDY [J].

CUNNINGHAM, AL ;

TURNER, RR ;

MILLER, AC ;

PARA, MF ;

MERIGAN, TC .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (01) :226-233

[8] Production of key molecules by ocular neutrophils early after herpetic infection of the cornea [J].

Daheshia, M ;

Kanangat, S ;

Rouse, BT .

EXPERIMENTAL EYE RESEARCH, 1998, 67 (06) :619-624

[9] Resistance to herpetic stromal keratitis in immunized B-cell-deficient mice [J].

Daheshia, M ;

Deshpande, S ;

Chun, S ;

Kuklin, NA ;

Rouse, BT .

VIROLOGY, 1999, 257 (01) :168-176

[10] Herpes simplex virus latency and the immune response [J].

Daheshia, M ;

Feldman, LT ;

Rouse, BT .

CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (04) :430-435

← 1 2 3 4 5 6 →